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A mass poisoning involving at least 1,860 individuals occurred in Kyushu, western Japan, in 1968. The incident is called Yusho oil disease because it was caused by the ingestion of rice bran oil that was contaminated with Kanechlor-400, a commercial brand of Japanese polychlorinated biphenyls (PCBs). It was later found that the rice bran oil had been contaminated not only with PCBs but also with polychlorinated dibenzofurans (PCDFs), polychlorinated quaterphenyls (PCQs), and other related compounds. Yusho is thus recognized as poisoning by a mixture of PCBs, dioxins and related compounds. For more than 35 years the patients with Yusho have suffered from various symptoms such as general malaise, headache, acneform eruption, dark-brownish nail pigmentation, increased discharge from the eyes with swelling of the eyelids, pigmentation of oral mucosa, peripheral neuropathy, irregular menstruation in women, and growth retardation in infants and children. We hereby publish the supplement entitled “Long-term effects of polychlorinated biphenyls and dioxins in humans
- Lessons from Yusho”. We hope the issue will help our understanding of intoxication with PCBs and dioxins in humans.

Masutaka Furue, Chief of the Study Group for Yusho
Department of Dermatology, Kyushu University, Maidashi 3-1-1,
Higashi-ku, Fukuoka, 812-8582, Japan
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サプリメント発刊に寄せて
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Long-term effects of polychlorinated biphenyls and dioxins in humans
- Lessons from Yusho (Supplement issue of Journal of Dermatological Science)


このたび油症に関する最近の学術的報告をサプリメントとして、Journal of Dermatological Science誌に 掲載いたしました。ここにそのPDFファイルを公開させていただきます。本誌が油症の病態の解明に 寄与することを期待したいと思います。
全国油症治療研究班 班長
九州大学皮膚科学教授 古江増隆