アトピー性皮膚炎 九州大学医学部皮膚科学教室TOPへ
シクロスポリン内服療法
研究協力者 藤本 学 金沢大学大学院医学系研究科皮膚科学
要旨 はじめに 研究目的 研究方法 結果 考察 結論 参考文献
シクロスポリン内服療法評価表一覧
評価表の見方
評価法の見方
参考文献
1) Camp, R. D., S. Reitamo, et al. Cyclosporin A in severe, therapy-resistant atopic dermatitis: report of an international workshop, April 1993. Br J Dermatol 129: 217-20, 1993
2) Wahlgren CF, Scheynius A, Hagermark O. Antipruritic effect of oral cyclosporin A in atopic dermatitis. Acta Derm Venereol 70: 323-9, 1990
3) Sowden JM, Berth-Jones J, et al. Double-blind, controlled, crossover study of cyclosporin in adults with severe refractory atopic dermatitis. Lancet 338: 137-40, 1991
4) Salek MS, Finlay AY, et al. Cyclosporin greatly improves the quality of life of adults with severe atopicdermatitis. A randomized, double-blind, placebo-controlled trial. Br J Dermatol 129: 422-30, 1993
5) van Joost T, Heule F, et al. Cyclosporin in atopic dermatitis: a multicentre placebo-controlled study. Br J Dermatol May 130: 634-40, 1994
6) Czech W, Brautigam M, et al. A body-weight-independent dosing regimen of cyclosporine microemulsion is effective in severe atopic dermatitis and improves the quality of life. J Am Acad Dermatol 42: 653-9, 2000
7) Zurbriggen B, Wuthrich B, et al. Comparison of two formulations of cyclosporin A in the treatment of severe atopic dermatitis. A double-blind, single-centre, cross-over pilot study. Dermatology 198: 56-60, 1999
8) Ross JS, Camp RD. Cyclosporin A in atopic dermatitis. Br J Dermatol 122 Suppl 36: 41-5, 1990
9) Zonneveld IM, De Rie MA, et al. The long-term safety and efficacy of cyclosporin in severe refractory atopic dermatitis: a comparison of two dosage regimens. Br J Dermatol 135 Suppl 48: 15-20, 1996
10) Sepp, N. and P. O. Fritsch. Can cyclosporin A induce permanent remission of atopic dermatitis? Br J Dermatol 128: 213-6, 1993
11) Berth-Jones, J., R. A. Graham-Brown, et al. Long-term efficacy and safety of cyclosporin in severe adult atopic dermatitis. Br J Dermatol 136: 76-81, 1997
12) Munro CS, Levell NJ, et al. Maintenance treatment with cyclosporin in atopic eczema. Br J Dermatol 130: 376-80, 1994
13) Granlund, H., P. Erkko, et al. Cyclosporin in atopic dermatitis: time to relapse and effect of intermittent therapy. Br J Dermatol 132: 106-12, 1995
14) Granlund H, Erkko P, Reitamo S. Long-term follow up of eczema patients treated with cyclosporin. Acta Derm Venereol 78: 40-3, 1998
15) 今山修平, 久保田由美子ほか. 重症アトピー性皮膚炎患者のサイクロスポリン治療: 臨床効果と作用機序の検討. 西日皮膚 54: 1141-7, 1992
16) 久保田由美子, 今山修平ほか. アトピー性皮膚炎の免疫抑制療法-サイクロスポリンの長期投与の効果と安全性についての検討- 西日皮膚 61: 271-8, 1999
17) Harper JI, Ahmed I, et al. Cyclosporin for severe childhood atopic dermatitis: short course versus continuous therapy. Br J Dermatol 142: 52-8, 2000
18) Campbell D, Kemp A. Cyclosporion restores cytokine imbalance in childhood atopic dermatitis. J allergy Clin Immunol 99: 857-9, 1997
19) Berth-Jones J, Finaly A, et al. Cyclosporin in severe childhood atopic dermatitis: A multicenter study. J Am Acad Dermatol 34: 1016-21, 1996
20) Zaki, I., R. Emerson, et al. Treatment of severe atopic dermatitis in childhood with cyclosporin. Br J Dermatol 135 Suppl 48: 21-4, 1996
21) Schmitt J, Schmitt N, Meurer M: Cyclosporin in the treatment of patients with atopic eczema - a systematic review and meta-analysis, J Eur Acad Dermatol Venereol 21:606-19, 2007
22) Hijnen DJ, ten Berge O, Timmer-de Mik L, Bruijnzeel-Koomen CA, de Bruin-Weller MS: Efficacy and safety of long-term treatment with cyclosporin A for atopic dermatitis, J Eur Acad Dermatol Venereol, 21:85-9, 2007
23) Pacor ML, Di Lorenzo G, Martinelli N, Mansueto P, Rini GB, Corrocher R: Comparing tacrolimus ointment and oral cyclosporine in adult patients affected by atopic dermatitis: a randomized study, Clin Exp Allergy, 34:639-45, 2004
24) ネオーラルによるアトピー性皮膚炎治療研究会:重症成人型アトピー性皮膚炎を対象としたシクロスポリンMEPCの前期第II相試験:多施設共同、ランダム化、オープンラベル、並行群間比較試験 西日皮膚, 70:541-51, 2008
25) ネオーラルによるアトピー性皮膚炎治療研究会:成人の重症アトピー性皮膚炎患者を対象としたシクロスポリンMEPCとプラセボとの比較試験:多施設共同、ランダム化、二重盲検、並行群間比較試験 臨皮, 63:73-82, 2009
26) ネオーラルによるアトピー性皮膚炎治療研究会:成人の重症アトピー性皮膚炎患者に対するシクロスポリンMEPC間歇投与法の安全性および有効性評価:多施設共同、オープン、長期間観察試験 臨皮, 63:163-171, 2009
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九州大学医学部皮膚科学教室TOPへ