アトピー性皮膚炎 九州大学医学部皮膚科学教室TOPへ
抗ヒスタミン薬・抗アレルギー薬
溝口昌子、上西香子
*聖マリアンナ医科大学皮膚科
要旨 はじめに 研究目的 方法 結果 考察 参考文献
抗ヒスタミン薬・抗アレルギー薬評価表一覧
評価表の見方
評価法の見方
参考文献
1) Hoare C, Li WanPo A, Williams H. Systematic review of treatments for atopic eczema. Health Technology Assessment 4 : 1-191, 2000
2) Klein PA, Clark RAF. An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis . Arch Dermatol 135: 1522-1525, 1999
3) Simons FER, Simons KJ, Becker AB, Haydey RP. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermaitits. J Pediatr 104:123-7, 1984
4) Klein GL, Galant SP. A comparison of the antipruritic efficacy of hydroxyzine and cyprohepatadine in children with atopic dermatitis. Ann Allergy 44:142-5, 1980
5) Munday J, Bloomfield R, Goldman M, Robey H, Kitowska GJ, Gwiezdziski Z, Wankiewicz A, Marks R, Protas-Drozd F, Mikaszewska M. Chlorpheniramine is no more effective than placebo in relieveing the symptoms of childhood atopic dermatitis with a nocturnal itching and scratching component. Dermatology 205:40-5, 2002
6) Doherty V, Sylvester DG, Kennedy CT, Harvey SG, Calthrop JG, Gibson JR. Treatment of itching in atopic eczema with antihistamines with a low sedative profile. BMJ 298:96, 1989
7) 濱田稔夫,石井正光,中川浩一,小林裕美,北島淳一,茶之木美也子,佐藤時子,谷幸子,八代典子. アトピー性皮膚炎に対するテルフェナジンの有用性の臨床的検討-薬効ランクstrongのステロイド外用薬単独とmildの外用薬にテルフェナジン併用との比較試験-. 皮膚38:97-103, 1996
8) Zuluaga de Cadena A, Ochoa de VA, Donado JH, Mejia JI, Chamah HM, Montoya de Restrepo F. Estudio comparativo del efecto de la hidroxicina la terfenadina y el astemizol en ninos con dermatitis atopica: Hospital General de Medellin-Centro de Especialistas C.E.S. 1986-1988 [ Comparative study of the effect of the hidroxicina the terfenadina and the astemizol in children with atopic demratitis : Hospital General de Medellin-Centro de Especialistas C.E.S. 1986-1988.] CES Med 3:7-13, 1989
9) Hjorth N. Terfenadine in the treatment of chronic idiopathic urticaria and atopic dermatitis. Cutis 42 (4A) :29-30, 1988
10) Berth-Jones J, Graham-Brown RA. Failure of terfenadine in relieving the pruritus of atopic dermatitis. Br J Dermatol 121 (5) :635-7, 1989
11) Wahlgren CF, Hagermark O, Bergstrom R. The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis. Br J Dermatol 122 (4) :545-51, 1990
12) Hannuksela M, Kalimo K, Lammintausta K, Mattila T, Turjanmaa K, Varjonen E, et al. Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults. Ann Allergy 70: 127-33, 1993
13) La Rosa M, Ranno C, Musarra I, Guglielmo F, Corrias A, Bellanti JA. Double-blind study of cetirizine in atopic eczema in children. Ann Allergy 73 (2) : 117-22, 1994
14) Patel P, Gratton D, Eckstein G, Aberer W, Pryzbilla B, Chelly M, et al. A double-blind study of loratadine and cetirizine in atopic dermatitis. J Dermatol Treat 8:249-53, 1997
15) Henz BM, Metzenauer P, O'Keefe E, Zuberbier T. Differential effects of new-generation h1-receptor antagonists in pruritic dermatoses. Allergy 53:180-3, 1998
16) Simons FER. Prospective, long-term safety evaluation of the H1-receptor antagonisit cetirizine in very young children with atopic dermatitis. J Allergy Clin Immunol 104: 433-40, 1999
17) Monroe EW. Relative efficacy and safety of Ioratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis. Clin Ther 14:17-21, 1992
18) Langeland T, Fagertun HE, Larsen S. Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis. A multi-crossover-designed study. Allergy 49:22-6, 1994
19) 石橋康正,上田宏,新村眞人,原田昭太郎,玉置邦彦,今村貞夫,山本昇壮,吉田彦太郎. 幼・小児のアトピー性皮膚炎に対するE-0659の臨床評価―多施設二重盲検法による用量比較試験. 皮膚31:458-471, 1989
20) 石橋康正,吉田彦太郎,新村眞人,原田昭太郎,玉置邦彦,上田宏,今村貞夫,山本昇壮. アトピー性皮膚炎に対するE-0659の臨床評価―Ketotifenを対照薬とした多施設二重盲検試験―.臨床評価17:77-115, 1989
21) 幡本明利,利谷昭治.アトピー性皮膚炎に対する塩酸アゼラスチン(アゼプチン®)の臨床効果の検討―抗ヒスタミン薬(フマル酸クレマスチン)との比較検討―.西日皮膚56: 1213-1220, 1994
22) Yoshida H, Niimura M, Ueda H, Imamura S, Yamamoto S, Kukita A. Clinical evaluation of ketotifen syrup on atopic dermatitis: a conparative multicenter double-blind study of ketotifen and clemastine. Ann Allergy 62: 507-512
23) Kawashima M, Tango T, Noguchi T, Inagi M, Nakagawa H, Harada S. Addition of fexofenadine to topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study. Br J Dermatol 148: 1212-1221, 2003
24) Savin JA, Dow R, Harlow BJ, Massey H, Yee KF. The effect of a new non-sedative h1-receptor antagonist (LN2974) on the itching and scratching of patients with atopic eczema. Clin Exp Dermatol 11 :600-2, 1986
25) 向井秀樹,石橋康正,西川武二,吉田彦太郎,西山茂夫.成人型アトピー性皮膚炎に対する抗アレルギー剤の有用性の検討―ステロイド外用剤単独とオキサトミド併用の比較試験―.西日皮膚51: 995-1002, 1989
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九州大学医学部皮膚科学教室TOPへ